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Under cystine deprivation conditions, ferritinophagy is activated to promote NCOA4-regulated ferritin degradation

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We therefore suggest a mechanism that can be described according to the Cleland nomenclature as a combination of a random bi-uni mechanism and a ping-pong bi-bi (or uni-uni-uni-uni) mechanism in which the single product of the rate-limiting random mechanism becomes the first substrate of the ping-pong mechanism (Fig