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Because semaglutide affects both metabolism and immune signaling, it is possible that it might have unexpected effects on the skin

To provide the right care for patients taking GLP-1s, physical therapists and care teams must be versed on the impact that obesity and diabetes have on the entire MSK system, particularly diminished tendon health, impaired muscle function and joint degradation

Microdosing GLP-1 means using doses significantly below the approved therapeutic range, but this practice lacks clinical trial evidence and is not approved by the MHRA

[10] [11] For weight management, NICE technology appraisals (TA875 for Wegovy, TA664 for Saxenda) provide specific BMI criteria and usage recommendations