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Weight regain is common after discontinuing weight loss medications, particularly without sustained lifestyle changes

Mice were housed in the animal facilities at the University of Illinois at Chicago, Research Resources Center, and the studies were approved by the Institutional Animal Care and Use Committee, which is certified by the American Association of Accreditation of Laboratory Animal Care

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Importantly, many peptide programs historically failed not because they were scientifically unsound, but because they were misaligned with regulatory frameworks, economic realities, or the prevailing standards of evidence at the time of evaluation