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En un estudio clnico multicntrico europeo, la suplementacin con L-carnitina (en forma de propionil-L-carnitina a 2 g/da durante 12 meses) en pacientes con claudicacin moderada a severa relacionada con la distancia mxima recorrida y la calidad de vida percibida logr una mejora significativa en comparacin con los pacientes que solo recibieron placebos
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Although a prior cohort study did not show a statistically significant reduction in major cardiovascular events among patients with no previous history of cardiovascular disease [148], a meta-analysis of eight clinical trials evaluating the effect of GLP-1R agonists on cardiovascular outcomes reported a 14% reduction in major adverse cardiovascular events, with no significant heterogeneity across GLP-1R agonists or subgroups, including patients with or without previous cardiovascular disease [149]
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