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Per the program's published design paper (Giblin et al., Diabetes, Obesity and Metabolism , 2026), the core registrational program consists of four trials : TRIUMPH-1 (NCT05929066): 80-week weight management basket trial, adults with obesity/overweight without diabetes (N=2,339), with knee osteoarthritis and obstructive sleep apnea substudies nested inside it
The missing zinc: p53 misfolding and cancer
Meanwhile, in vivo studies revealed that compound 58 (Figure 7) exhibited efficacy comparable to sitagliptin at a dosage of 10 mg/kg
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