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GHK-Cu exerts its effects primarily through gene expression modulation, influencing approximately 31% of the human genome by upregulating genes involved in antioxidant responses, DNA repair, protein metabolism, and cellular growth while downregulating inflammatory mediators, fibrinogen synthesis, and pathological processes including cancer metastasis
Topical serums on intact skin produce modest results (7% at 16 weeks)
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Its stability in vitro is limited, with a half-life of roughly 15 minutes, but in vivo it may form complexes with carrier proteins or exist as part of a larger precursor molecule to resist degradation
