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TMT liquid chromatography mass-spectrometry Samples were analyzed by liquid chromatography tandem mass spectrometry

Obesity, smoking, sleep disorders and chronic nutritional deficiencies also contribute to the increase in pigmentation

Lipid metabolism TLR-mediated inflammatory processes are intricately linked to lipid metabolism, with bidirectional influence where lipid metabolism alterations regulate TLR signaling, endocytosis, and cytokine secretion

While these nutrients have shown depigmentation effect on skin in initial studies, further large-scale human trials are needed for confirmation of these effects of specific food items