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It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
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It is prescribed to prevent stroke and systemic embolism in patients with non-valvular atrial fibrillation, to treat or prevent deep vein thrombosis (DVT) and pulmonary embolism (PE), and for prevention of VTE following hip or knee replacement surgery
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