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Despite with picomolar-level detection capacity, most of the current nanomaterial-based GSH biosensors (Table 1) present several drawbacks for wider biological applications, such as its potential toxicity and immunogenicity, reproducibility on the synthesis of nanomaterials, etc 70

Therapeutic strategies targeting HMGB1 may offer a novel approach in the treatment of MASLD [228, 229]

Glutathione stabilizes the inner mitochondrial membrane, squelches reactive oxygen species (ROS) generated by mitochondrial respiration, and maintains mitochondrial DNA fidelity to profoundly influence mitochondrial function and cell survival

Abbreviations TT: Testicular torsion I/R: Ischemiareperfusion IR-I: Ischemiareperfusion injury PRP: Platelet-rich plasma PC: Post-conditioning LT: Left testis i.t: Intratesticular i.p: Intraperitoneally MDA: Malondialdehyde CAT: Catalase GSH: Reduced glutathione eNOS: Endothelial nitric oxide synthase HSP70: Heat shock protein 70 VEGF: Vascular endothelial growth factor TNF-: Tumor necrosis factor alpha IL-6: Interleukin-6 NF-B: Nuclear factor kappa B Bax: Bcl-2-associated X protein ROS: Reactive oxygen species PAS: Periodic acidSchiff H&E: Hematoxylin and eosin Hb: Hemoglobin RBCs: Red blood cells HCT (PCV): Hematocrit (packed cell volume) MCV: Mean corpuscular volume MCH: Mean corpuscular hemoglobin MCHC: Mean corpuscular hemoglobin concentration References Akhigbe, R