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Clinicians should maintain a low threshold for evaluating persistent gastrointestinal symptoms, as distinguishing medication side effects from other acute conditions requires clinical judgment
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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem
Some polysaccharides can also induce mild ROS generation in cancer cells, pushing them beyond their oxidative threshold and triggering cell death, all while protecting normal cellsan effect linked to the activation of endogenous antioxidant pathways like Nrf2 (137)
