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showed that the activation of ferroptosis by erastin increased the levels of lysosome-associated membrane protein 2a (LAMP2A) to promote CMA, which, in turn, triggered the degradation of GPX4

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Nat Commun 12:4957

Generally, Gln is transported into the cytoplasm or out of cells with the help of membrane transporters such as SLC1A5, SLC38A1, and SLC38A2 ( Figure 1 ) ( via the surface transporter protein SLC7A5 ( Figure 1 ) ( Figure 1 ) ( via the SLC1A5 variant ( Figure 1 ) ( Figure 1 ) ( Figure 1 ) ( Figure 1 ) ( via the transporter protein SLC25A18, and then the Glu in the cytosol is involved in the biosynthesis of glutathione and nonessential amino acids (NEAAs) ( Figure 1 ) ( Figure 1 ) ( Figure 1 3 The key role of glutaminolysis in the immune system and T cells Gln has been reported to be essential for the biological process of proliferation and differentiation and survival of immune cells, protecting from various pathogens ( 3.1 Innate immune system The immune system is made up of the innate immune system and the acquired immune system ( 3.1.1 Glutamine and skin As the first line of defense of the organism, intact skin is a primary physical barrier against the invasion of harmful organisms ( 3.1.2 Glutamine and intestinal immunity As a complex, multicellular organ, the intestine performs numerous physiological functions that are critical in enteral nutrition ( via the rectal route in a rat colitis model downregulated the expression of regulatory inflammatory transcription factors (STAT1 and STAT5) and inflammatory factors, which alleviated the inflammatory effects of colitis ( 3.2 Acquired immune system: T cell implication The acquired immune system is the most important component of the immune system, removing specific pathogens that infect the body, which is mainly mediated by T cells ( + T helper cells (Th) and CD8 + cytotoxic T lymphocytes (CTL) ( + T cells are indirectly involved in the clearance of infections by regulating the activity of other immune cells such as macrophages, neutrophils, B cells and CTL