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Over one-third of patients with type 2 diabetes were classified as non-responders compared to less than a quarter of patients without diabetes (without type 2 diabetes: 77.3% responders and 22.7% non-responders
Observational cohorts have mixed findings, and confounding by weight loss and diet is common
A Phase II study also documented beneficial effects of the NDP-MSH analog in acne vulgaris, consistent with anti-inflammatory melanocortin signaling in skin (Bohm et al., 2012)
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