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GLP-1 is a hormone released from the gut after meals that: Stimulates insulin release when blood sugar is high Reduces glucagon levels Slows stomach emptying Signals satiety to the brain Modern GLP-1based medications (semaglutide alone and tirzepatide as a dual GIP/GLP-1 agonist) mimic or combine these effects

(3) While this is a small research sample, another source also confirmed an increase skin thickness, hydration and elasticity

Pediatric drug development follows a staged approach, beginning with older adolescents before moving to younger children

This is particularly concerning given that dehydration may increase the risk of acute kidney injury, a rare but serious adverse effect associated with severe gastrointestinal reactions to GLP-1 receptor agonists