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GLP-1 receptors are distributed across multiple brain regions, each contributing to distinct physiological and behavioural functions
230 adults who are obese or overweight (average BMI ~39.5) were randomly assigned to take a placebo, or aleniglipron at one of three doses (45mg, 90mg, or 120mg) for 36 weeks, with the dose gradually increasing over time
The specific rationale for adding glucagon receptor agonism to the GIP/GLP-1 dual agonist framework was grounded in preclinical evidence that glucagon promotes energy expenditure and hepatic lipid oxidation
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