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Tortuous, immature and unevenly perfused vessels create spatial heterogeneity in vascular access, oxygenation, acidity and drug distribution [11, 12, 15, 68]
Age at baseline was calculated from the index date and date of birth
Theranostics, which merges therapeutic and diagnostic functionalities into a single entity, is another area of promise, as biochemically cleavable conjugations can enable real-time monitoring of treatment efficacy while delivering therapeutic agents to target sites
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doi: 10.3390/vaccines10122004 81 IshayAShachamEC
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