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Some have data from randomised controlled trials in humans, while others rely mainly on animal research and mechanistic studies
So what remained, however, and remains today, was that people have trouble maintaining the weight loss
doi: 10.1016/j.freeradbiomed.2013.07.036 55 HarrisAGWilsonJEDanonSJDixonMFDoneganKHazellSL
The medication works by slowing gastric emptying, increasing feelings of fullness, and resetting hunger signals in the brain
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