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GLP-1s increased the release of insulin but had an extremely short half-life (one to two minutes), making them highly unfavorable as a treatment for diabetes

The work of Zhang and colleagues is important for physicians who treat diabetes because class B G protein-coupled receptors (GPCRs) are important therapeutic targets

PMID: 285 AgrawalPJainNGopalanVTimonASinghARajagopalPSet al