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The first dose and dose increases are typically when side effects are most pronounced
Some peptides occur naturally, regulating everyday functions like appetite, digestion, and metabolism, while others are synthesized to mimic or amplify those same natural signals
Unlike the other gut-derived substance secreted from enteroendocrine cells, serotonin (5-hydroxytryptamin: 5-HT) is not a peptide but is derived from the amino acid tryptophan
In SURMOUNT-1 the 15 mg arm averaged 22.5% body weight loss at 72 weeks, only modestly higher than the 10 mg arm at 21.4%
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