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GSH depletion has been identified as an early-stage event in the pathogenesis of Parkinson's disease, occurring before the loss of dopaminergic neurons becomes clinically apparent
Acknowledgements This work was supported by NIH grant R01 CA79882 to JMS from the National Cancer Institute and by a Predoctoral Fellowship in Pharmacology by Pharmaceutical Research and Manufacturers of America Foundation awarded to Austin M Dulak
This results in a darker complexion
First, both used slow dose escalation specifically because the gastrointestinal effects are dose-related
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