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The DAC version includes a Drug Affinity Complex that extends the half-life in research models
Example 8 Coupling of the peptide resin fragment, PEG-PEG- -Glu-Octadecanedioic Acid mono-tert-butyl ester Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and octadecanedioic acid mono-tert-butyl ester were sequentially coupled by conventional amino acid coupling
NICE has not yet issued guidance on retatrutide, as technology appraisal is contingent upon a medicine receiving a marketing authorisation
Rheumatology 44 , 126129 (2005)
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