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Hedgehog signaling and BMP4 facilitates the proliferation of fetal HPCs in vitro (Wang et al., 2015), while TGF signaling remarkably inhibits HPC colony formation in vitiro ( Our lab established a protocol consisting of EGF, CHIR, E616452 and two bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate, hereafter termed as ECELS

These changes can result in slower information processing, reduced motor coordination, and increased cognitive inflexibility (Yang et al., 2018)

Angiogenesis generates vascular niches to support and maintain the stemness of CSCs

Severe gastrointestinal condition (gastroparesis, inflammatory bowel disease) 10