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GLP-1 receptor agonists improve insulin sensitivity, enhance cerebral blood flow, and reduce neuroinflammatory signaling, addressing upstream defects in glucose delivery and utilization

Antioxidants & redox signaling 13 , 14291476, doi: 10.1089/ars.2009.3029 (2010)

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The lower bioavailability actually works in favor here, as the body receives the active compound more gradually throughout the day rather than in a single bolus that can overwhelm GLP-1 receptors in the gut