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A primary concern in any growth-promoting therapy is the regulation of insulin-like growth factor 1 (IGF-1)

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doi:10.1007/s00125-023-05956-x Qureshi N, Wesolowicz L, Stievater T, Lin AT

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The cardiovascular evidence is the most solid: in the SELECT trial, people with obesity and established heart disease who added semaglutide cut their risk of cardiovascular death, a second stroke, or a second heart attack by about 20%

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USADA and other anti-doping organizations have spent years warning athletes about the potential legal and eligibility risks of using unapproved substances whether via prescription drugs or unvetted supplements while also articulating the health risks for elite athletes and others looking to gain a small advantage in the gym

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