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Future frameworks will likely need to incorporate guidance for engineered strains, synbiotics, microbial consortia, and microbiome-based therapeutics, extending the FAO/WHO principles to more complex products while maintaining their core focus on strain specificity, safety, and evidence-based health benefits (531)

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doi: 10.1007/s11033-021-07077-3 (Online ahead of print) 17 DengY.ZhengH.YanZ.LiaoD.LiC.ZhouJ.et al

Prescription options: Deplin [L-methylfolate from Metafolin] (7.5 and 15mg) Generic L-methylfolate (7.5 and 15mg) EnLyte with DeltaFolate [A combination of L-methylfolate, folinic acid, and folic acid] Many OTC options: Considerations include the amount of methylfolate, the ratio of stereoisomers, and the type of folate salt as this will impact the bioavailability of the product