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Addiction 110 (5), 823831
Key evidence points: GLP-1 medications do not directly target or break down muscle tissue Lean mass loss occurs as a consequence of the calorie deficit and weight reduction The proportion of lean mass lost is comparable to other weight loss methods Greater absolute lean mass loss reflects the greater total weight loss achieved Regulatory bodies including NICE and the MHRA have not identified muscle loss as a specific adverse effect requiring special warnings in the Summary of Product Characteristics (SmPCs), though healthcare professionals are advised to monitor nutritional status and encourage appropriate dietary protein intake and physical activity in patients using these medications for weight management
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(Mounjaro, Zepbound) and rival Novo Nordisk A/S (Ozempic, Wegovy) have become a veritable gold mine, one projected to reach $100 billion within the next seven years
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