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Combination antithrombotic therapy, including GLP-1 receptor agonists, further exacerbates this risk [142]
Dose increases can temporarily worsen constipation because digestion slows further
Importantly, targeting of MK-801 to GLP-1 receptor-expressing brain regions circumvents adverse physiological and behavioural effects associated with MK-801 monotherapy
Exclusion criteria include UC complications, other forms of colitis, ostomy, primary sclerosing cholangitis, pregnancy, recent malignancy, and specific infections including C
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