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Research has also examined its role in enteric neuron survival, enteric glial cell activity, gut motility modulation, and gut-brain axis signaling in experimental settings
However, the immunomodulatory benefits of PRLM supplementation or upregulation in long-term smokers remain insufficiently validated in clinical studies, partly because of challenges in study design and population heterogeneity
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Most healthcare professionals recommend starting with 0.25 mg once a week for four weeks, then increasing to 0.5 mg, ultimately reaching the maintenance dose of 2.4 mg per week
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