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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression
Side effects with survodutide were in line with those expected for GLP-1 RAs and were the principal cause of discontinuation 24.6% in the survodutide groups versus 3.9% with placebo
These GI effects are the best-supported use in animal data
The albuminuria reduction with tirzepatide was observed irrespective of RAS inhibitor or SGLT2i use, which are current guideline-recommended treatments to slow the progression of CKD
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