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These trials were a key step in demonstrating the efficacy of these drugs in terms of weight management and metabolic improvements for individuals with type 2 diabetes [8,9]
Several head-to-head trials, including the SURMOUNT and STEP studies, compared outcomes for both medications
Retatrutide affects insulin response, while MOTS-c affects AMPK and muscle glucose uptake
(30,31) The authors acknowledged several limitations, including the use of a national patient database, which restricted their ability to control for prior diabetes management and preoperative glycemic control
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