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Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models
Due to multiple probe sets mapping to the same gene, we converted the fold changes in m-RNA production produced by GenePattern to percentages, then averaged all probe sets representing the same gene
The consequence is that we cannot confidently answer basic clinical questions: What is the maximum tolerated dose in humans
This emphasizes the significant role of vitamin B12 in DNA synthesis, myelin sheath maintenance, and cell metabolism, underscoring its essential contribution to promoting good health
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