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368,369,370 HSF2 and DLG2 can block the oligomerization of ASC by interfering with the interaction between ASC and NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the upregulation of IL-1 expression and alleviating the inflammatory response
Glucagon like peptide-1 (GLP-1) is the natural ligand of GLP-1R
In the clinical trial, patients on the highest dose lost about 25 lbs or approximately 11% of their body weight over 72 weeks
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