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A 70-year-old woman, 52, started semaglutide at 313 pounds

SystemsAge was calculated using the methylCIPHER package ( The Intrinsic Capacity epigenetic clock was calculated using code available at DNAmFitAge and additional epigenetic metrics were calculated via TruDiagnostics DNAm Analysis Software, available at no cost for research purposes upon request ( access requires agreement to a standard noncommercial software license for academic, nonprofit research use

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In a 68-week placebo-controlled trial, once-weekly semaglutide (Ozempic, Wegovy) injections in people with obesity and moderate knee osteoarthritis produced significantly greater reductions in body weight along with significant improvements in pain scores and better physical function