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Intervention studies have shown that weight reduction in PwO through caloric restriction alone or in combination with low-impact aerobic exercise results in increased levels of BTMs and decreased BMD values [29, 30]
We emphasize that lifestyle work often reduces the total medication burden and improves long-term outcomes
In an interview, Martin Lange, Novos head of development, said he so far hasnt seen evidence of the drug affecting childrens growth and development, but our commitment is to investigate our drugs in all populations where we get approved, so that would be part of our commitment to continue to to assess that. Even before this new data on young children, experts were already conflicted on how to address obesity in teenagers
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