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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide

Disturbed flow promotes endothelial senescence via a p53-dependent pathway

These mice were injected with the drugs i.p

In contrast, the AIs set by EFSA (2015) as an intake goal for individuals in all life-stage and physiological groups, are higher than those set by the IOM (2000)