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These enzymes function as multi-subunit complexes, where the catalytic activity is provided by the SET domain within the MLL proteins located near the C -terminus for their intrinsic methyltransferase activity, which is weak in the absence of the core subunits (WDR5, RBBP5, ASH2L, and DPY30) (Ruthenburg et al., 2007)
NAPQI is detoxified and subsequently excreted by glutathione (GSH)
DSIP is not listed as a scheduled controlled substance under the international drug-control conventions or under the major national scheduling systems
[published online ahead of print, 2022 Apr 20]
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