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Future research should prioritize elucidating the molecular mechanisms behind the antitumor effects, refining individualized treatment strategies, investigating early tumor prevention applications, assessing potential benefits for non-diabetic populations, advancing the development of novel therapies, establishing robust safety monitoring frameworks, and building precision medicine decision-making platforms
MT-II has been associated with serious side effects like muscle tissue breakdown (rhabdomyolysis), kidney dysfunction, prolonged, painful erections (priapism), stroke, darkening of existing moles, new atypical moles increasing melanoma risk, and swelling of the brain
doi: 10.3389/fendo.2018.00725 Received 17 August 2018 Accepted 15 November 2018 Published 29 November 2018 Volume 9 - 2018 Edited by Richard Ivell, University of Nottingham, United Kingdom Reviewed by Giuliano Marchetti Bedoschi, Universidade de So Paulo, Brazil
In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]
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