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SA Figure S2 shows that while they started off with 8,803 in the Semaglutide and 8,801 in the Placebo group, they ended at 48 months with only 712 in the Semaglutide group and 708 in the Placebo group at which point the graph juststops

These concerns were initially based on biological evidence indicating that the incretin system and the GLP-1-receptor might play a role in the development of cholangiocarcinoma [5,6,7], and further highlighted by an observational study using data from the UK Clinical Practice Research Datalink [8] showing that use of DPP4 inhibitors, compared with other second- or third-line glucose-lowering drugs, was associated with an increased risk of cholangiocarcinoma (HR 1.77 [95% CI 1.04, 3.01])

Microbial modification of bile acids is an important component of gut-liver axis function

A refund guarantee and a treatment-outcome guarantee are not the same thing, and marketing language is not the same as a written policy