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In the late stages of PD, the key molecular pathogenic mechanisms include the misfolding and aggregation of -synuclein, mitochondrial dysfunction, impaired protein clearance (related to inefficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxidative stress (57)

46 47 The bone benefits are more modestlong-term EMS use may slightly improve spine bone density and slow bone loss in postmenopausal and osteopenic women 48 but traditional resistance training still outperforms it on that front

This is a normal part of aging but can be accelerated by long-term use of medication or an unhealthy lifestyle