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(2007, Nature Cell Biology ) showed Thymosin Beta-4 promotes myocardial regeneration through epicardial cell priming a finding that greatly expanded TB-500 research interest

In laboratory research settings, GHK-Cu has been investigated for its effects on fibroblast gene expression profiles, collagen and glycosaminoglycan synthesis characterization in cell culture models, and antioxidant enzyme upregulation via Nrf2 pathway activation