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PLoS Biol 2018;16:e2006203

What happens to darker freckles

Chiao YA, Zhang H, Sweetwyne M, Whitson J, Ting YS, Basisty N, Pino LK, Quarles E, Nguyen NH, Campbell MD, Zhang T, Gaffrey MJ, Merrihew G, Wang L, Yue Y, Duan D, Granzier HL, Szeto HH, Qian WJ, Marcinek D, MacCoss MJ, Rabinovitch P

More than 12 well-designed randomized controlled research studies failed to demonstrate any effect of secretin, a gastrointestinal hormone, on ASD symptoms