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Cautions DO NOT TAKE large doses of vitamins (megadoses or megavitamin therapy) unless directed to by your doctor

Liver-related morbidity and mortality are highest in more advanced fibrotic NASH, which has led to an early focus on anti-fibrotic approaches to prevent progression to cirrhosis and HCC

Contact your GP or trial clinician promptly if you notice: A persistent increase in resting heart rate without an obvious cause Mild but recurrent palpitations or an awareness of your heartbeat Unexplained fatigue or reduced exercise tolerance New or worsening breathlessness during everyday activities It is worth noting that some degree of heart rate elevation may be an expected pharmacological effect of retatrutide, as discussed above

Patients should contact their GP or diabetes specialist nurse if diarrhoea is severe, persistent (lasting more than a few days), or significantly affecting their daily activities and quality of life