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These benefits were associated with a rebalancing of the cytokine milieureducing pro-inflammatory IL-6, IL-1, and TNF- while elevating anti-inflammatory TGF-1mediated by the suppression of the MAPK signaling pathway [76]
[26] [27] They are generally safe but contraindicated with nitrate medications and riociguat, and require caution in men with cardiovascular disease or those taking alpha-blockers
Rapid weight loss, particularly to Ozempic face, is a common side effect that has caused some patients to develop facial changes, such as sagging or volume loss
Yang, J
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