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Deletion of PLC-3 or PLC-4 genes showed no phenotypic effects in mice, but sperms from PLC-4-deficient mice showed a defective acrosomal reaction, a process required for fertilization ( PLC- PLC-, first identified in Caenorhabditis elegans , is the largest PLC isoform cloned to date, with a molecular weight of 250 kDa
Managing nausea and vomiting whilst on GLP-1 treatments Dietary adjustments Eat smaller, more frequent meals rather than three large ones Avoid very fatty, spicy, or rich foods that may aggravate symptoms Try bland, easily digestible foods like toast, crackers and rice when feeling queasy Ginger or peppermint teas may help settle the stomach Stay well-hydrated with small, frequent sips of cold water or electrolyte solutions Timing strategies Take medication at bedtime if prescribed this way, so you might sleep through the worst symptoms Eat before taking your injection (if advised by your healthcare provider) Wait 1-2 hours after your injection before eating if taking with meals worsens symptoms Lifestyle modifications Avoid lying down immediately after eating Practise deep breathing when waves of nausea strike Consider acupressure wristbands designed for motion sickness Maintain good ventilation in your eating environment Avoid strong odours that might trigger nausea Medical approaches Anti-nausea medications such as cyclizine, or ondansetron may be prescribed for severe cases Follow the prescribed dosing schedule carefully
doi: 10.1186/s12890-021-01422-9 292 WestA
MDHAR, MDAR1 and ATMDAR2 catalyze the conversion of monodehydroascorbate to ascorbate (Chew et al., 2003)
