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For example, GLP-1 receptor agonists such as semaglutide and tirzepatide improve insulin sensitivity, lower A1c, and reduce visceral fat while preserving lean muscle mass one of the most critical tissues for long-term metabolic health

its theoretical advantage (physiological sleep architecture modulation without sedation) has not been confirmed by adequately powered trials

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It shares a high degree of sequence similarity in the TMD region with GLP-1R (61%) that has been studied extensively both structurally and functionally