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Retatrutide is not approved by the FDA for any indication as of January 2025
Rare Side Effects Localized dryness or irritation with topical use in sensitive skin
Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes and obesity, have evolved into multi-organ potential therapeutics due to their pleiotropic effects beyond glycemic control
However, the relationship is the opposite for weight loss, with more weight loss observed with long-acting GLP-1RAs despite the lesser effect of these drugs on gastric emptying
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