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The available findings suggest that silymarin: Can positively influence LDL and VLDL cholesterol levels Significantly increased HDL cholesterol (the so-called "good cholesterol") in studies Can improve oxidative status in the bloodstream Can counteract the reduction of glutathione in the liver caused by a high-cholesterol diet These findings come from clinical studies that were, however, in some cases methodologically heterogeneous
others take a small dose every other week, or alternate weeks on and off the drug
Topicals work best when paired with internal supplementation
A small cup-to-disc ratio is the strongest risk factor for NAION
