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The thing is, the company had already submitted its application for approval before these results were released, and that application is based on earlier studies showing strong weight loss and blood sugar improvements on their own

Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies

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They also found that the Mcl-1 inhibitors were very selective and did not kill cells that rely on other members of the protein family