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As glucocorticoid concentrations in the blood rise, the hypothalamus and pituitary gland reduce their signaling to the adrenal glands to prevent additional glucocorticoid secretion (Figure 4

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Treatment effects based on data obtained from treatment completers A frequently used method to estimate the effect in randomized trials is through restricting the analysis set to comprising only data from patients who continue the randomized treatment until the scheduled end-of-treatment visit (i.e., treatment completers)