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In diabetes, HFpEF is predominantly driven by coronary microvascular disease/dysfunction, systemic inflammation, as well as cardiovascular autonomic dysfunction (which is very specific to diabetes) and a deficient heart oxidative metabolism, all leading to remodeling of the heart and increased stiffness, while HFrEF is predominantly driven by adverse remodeling secondary to accelerated atherosclerotic CVD (ASCVD)
In regard to this research, Pop-Busui reported personal fees from Novo Nordisk during the conduct of the study, as well as Bayer and Novo Nordisk, and personal fees from Lexicon, Roche Diagnostic, and Vertex outside the submitted work
Glutathione is a naturally occurring antioxidant in our body, composed of three amino acids: cysteine, glycine, and glutamic acid
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