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GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%
GSEA analysis revealed significant enrichment of IFN-I signaling pathways in the Lig group (Fig S6a), while the corresponding heatmap analysis confirmed upregulation of IFN-Iresponsive genes in Lig-derived neutrophils (Fig S6b)
These findings reinforce the view that obesity is a chronic, relapsing condition, and that ongoing treatment may be necessary to sustain the health benefits achieved with incretin-based therapies
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